Cognitive & neuro
N-Acetyl Semax amidate
A chemically modified Semax heptapeptide sold as a research chemical, with no human trials of the modified form.
What it is
N-acetyl Semax amidate is a modified version of Semax, a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that copies a fragment of ACTH(4-7) with a C-terminal Pro-Gly-Pro tail. Adding an acetyl group at one end and an amide at the other is intended to slow enzymatic breakdown. It is sold as a research chemical; only plain Semax holds any medicinal licence, and only in Russia and a few neighbouring countries.
How it works
- 1
The ACTH(4-7) core carries melanocortin-type signalling into the brain without stimulating steroid production.
- 2
Animal studies report increased BDNF and NGF expression in the hippocampus.
- 3
Reported modulation of dopaminergic and serotonergic transmission in rodent models.
- 4
The Pro-Gly-Pro tail is thought to slow peptidase breakdown.
- 5
The acetyl and amide caps are intended to resist exopeptidase digestion at both ends.
What it's studied for
Reported and studied effects
- No established human effects for the acetylated, amidated form
- Reported cognitive changes come from user reports, not controlled trials
- Purity and identity of grey-market product are unverifiable
Research protocol notes
Research context onlyResearch context only - there is no approved human protocol for this modified peptide. Animal work used microgram to milligram per kilogram doses, often intranasally, over days. Human intranasal Semax data come from Russian studies of the unmodified 0.1% solution, which the acetylated amidated variant has never been through.
These figures are described so you can understand what researchers did. They are not a dose, a schedule, or a suggestion — and they are not a substitute for a doctor.
Possible side effects and contraindications
Safety profile
Possible side effects
- Not established in humans
- Nasal irritation with intranasal use
- Theoretical melanocortin effects such as appetite or skin pigmentation change
- Unknown interactions and purity risks
Contraindications and cautions
- Pregnancy and breastfeeding
- No safety data in children
- Caution with autoimmune or psychiatric conditions
- Not a substitute for any approved treatment
A side-effect list is never complete, and these are not the only situations that warrant caution. Anything unexpected, or anything you are unsure about, should be discussed with a doctor before use.
Evidence assessment
No controlled human trials of the modified peptide exist; the evidence is animal work on related molecules plus uncontrolled user reports.
References
References link to published literature, regulator pages or literature indexes. Where a link points to a search, it collects the peer-reviewed work on that molecule rather than a single study.
Related
Related peptides
Other entries in Cognitive & neuro.
Cognitive & neuro
ACTH 4-10 (Org 2766)
The nerve-acting fragment of ACTH, developed as a drug candidate for nerve damage and cognitive decline, and abandoned.
Cognitive & neuro
BDNF (brain-derived neurotrophic factor)
The brain's main growth factor for plasticity: essential, widely measured, and not something a supplement can deliver.
Cognitive & neuro
Cerebrolysin
A porcine brain peptide mixture licensed in parts of Eastern Europe and Asia for stroke and dementia, without EMA or FDA approval.