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Pick up to three peptides to see how their mechanisms, studied uses and evidence levels differ. Rows where the entries disagree are marked with a blue edge.

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Comparison
MGF (mechano growth factor)

Growth hormone secretagogue

Evidence level
Anecdotal evidence
Approval status
Not approved
Mechanism of action
  1. 1.MGF is a splice variant of IGF-1 produced in muscle after mechanical damage.
  2. 2.In laboratory models it activates muscle stem cells and drives local repair.
  3. 3.The PEGylated form is designed to survive enzyme breakdown long enough to act.
  4. 4.Most effects described are local to the injected muscle, which is why users inject near the injury.
  5. 5.These mechanisms have not been demonstrated in controlled human studies.
Studied for
  • Muscle repair and hypertrophy in animal and cell models
  • Satellite cell activation research
  • Injury-recovery claims in sports settings
  • No human trials exist
Reported effects
  • Local muscle growth in animal models
  • Increased protein synthesis in laboratory tissue
  • Reported faster injury recovery in user accounts
  • Hypoglycaemia risk, as with the IGF-1 family
Side effects
  • Injection-site pain and swelling
  • Hypoglycaemia
  • Joint and jaw pain, as with the IGF-1 class
  • Possible promotion of existing cancers
  • Long-term safety unknown
Research protocol

Research context only — no human protocol exists. Laboratory work used microgram doses in cell and animal models. Schedules of 200–400 micrograms injected into a specific muscle after training come entirely from community practice, and there is no published human safety or efficacy data.

Research context only

Evidence justification
There are no controlled human studies of MGF; all available data come from cell and animal experiments plus user reports.