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Pick up to three peptides to see how their mechanisms, studied uses and evidence levels differ. Rows where the entries disagree are marked with a blue edge.
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Comparison
Humanin
Mitochondrial & antioxidant
Evidence level
Anecdotal evidence
Approval status
Not approved
Mechanism of action
- 1.A 24-amino-acid peptide encoded in mitochondrial DNA and released into the bloodstream.
- 2.Binds and blocks pro-apoptotic proteins, protecting cells from stress-induced death.
- 3.Improves insulin sensitivity and glucose handling in rodent models.
- 4.Acts on the hypothalamus and other tissues in animal studies of appetite and metabolism.
- 5.Circulating humanin falls with age and metabolic disease — correlation, not proof that raising it helps.
Studied for
- Ageing and metabolic research
- Insulin sensitivity in animal models
- Neuroprotection in laboratory studies
- Mitochondrial-derived peptide biology
Reported effects
- Improved insulin sensitivity in animal models
- Protection of cells from stress-induced death in laboratory studies
- Human observational links between low humanin levels and metabolic disease
- No confirmed clinical outcome from administered humanin
Side effects
- Not studied in humans
- Injection-site reactions
- Unknown effects on glucose control and blood pressure
- Long-term safety unknown
Research protocol
Research context only — no approved protocol exists. Rodent studies use microgram-to-milligram-per-kilogram doses, often by injection. A related analogue, humanin-G, has been tested in small human studies of cognitive and metabolic outcomes, but that is a different molecule. Any humanin injection schedule sold online has no trial basis.
Research context only
Evidence justification
Human humanin biology and its analogues have early clinical work, but administered humanin itself has no controlled human trials, so the evidence for using it is anecdotal.