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Pick up to three peptides to see how their mechanisms, studied uses and evidence levels differ. Rows where the entries disagree are marked with a blue edge.
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Comparison
Cortistatin
Cognitive & neuro
Evidence level
Anecdotal evidence
Approval status
Not approved
Mechanism of action
- 1.Binds somatostatin receptors, sharing some actions with somatostatin.
- 2.Also engages the ghrelin receptor in some tissues, unlike somatostatin.
- 3.Increases slow-wave sleep in rodents when given centrally.
- 4.Reduces inflammatory cytokine release from macrophages.
- 5.Modulates hippocampal synaptic transmission in slice studies.
Studied for
- Sleep architecture and slow-wave sleep in animals
- Memory consolidation and synaptic plasticity
- Inflammation and immune regulation in models
- Pain and seizure models
Reported effects
- Increased slow-wave sleep in rodent studies
- Anti-inflammatory effects in animal models
- No established human cognitive or sleep effect
Side effects
- Unknown in humans
- Theoretical effects on glucose and hormone regulation through somatostatin and ghrelin receptors
Research protocol
Research context only - no human protocol exists. Published work is in rodents, typically using central or intraperitoneal microgram doses over hours to days, and the human peptide differs slightly in length from the rodent form.
Research context only
Evidence justification
Rodent and cell data only, with no human dosing, safety information or trials.